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Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604

Withania somnifera suppresses tumor growth of intracranial allograft of glioma cells

MitsouEKSaxamiGStamoulouEKerezoudiETerziEKoutrotsiosGet al

Investigative Dermatology 133 (2), 528536

10.1016/j.cell.2022.06.003 71 SuiX.ZhangR.LiuS.DuanT.ZhaiL.ZhangM.et al (2018)